headache, aweating, laligue and joint pains precede acute onsel Proluae aweals and aacroillac arthralgia charactaniStic sympione Lymphadencpathy. sple

headache, aweating, laligue and joint pains precede acute onsel Proluae aweals and aacroillac arthralgia charactaniStic sympione Lymphadencpathy. splenomegaly and hepatomegaly may occur acute disease lasts for 2-4 waeks (b)LQCALISED DISEASE - (i) Joint Involvement - Back pain (due to sacro-ileite) or involvement of lurrtoar spine Affection of weight-bearing joinis such as hip or knee with swelling and tenderness due to inleclion of joint or reactive arthriltis Stemoclavcular. and motacarpophalangeal and coatochandral Joints may be involved, (u) Cardiac involvernent - Endncardis affecting aortic valve rare (III) Neurological Involvement rare Memngits Radcultts presenting as sciafca or Cauda equina ayntfome Encephalopalhy, myetopaihy, cranial nerve palsies, transleni ischerris episodes, vascular occlusion in brain and spinal cord and ruptured rrycotic aneuiysm. (iv) Miscellaneous - Skin - Red. papular skin eruption mainly on the extremities, measles-like rash or pustular lesions Epitddymo-orchilis igA nephropathy Lung liver. spleen and eye irvolvement 2 Subacute brucellosis - Illness falls to resolve aftai 4 weeks, or exacerbations occur after this time Muscle weakness and extreme Fallgue may be mtslakenlor naurose. Painful joints Periods of good health intended by synptons 3. Chronic brucellosis - Recurring exac aibations persisting for many years Clncal picture resembles repealed attacks of influenza Fever uncommon LocalsEation of trucetia in liver, spleen, bone marrow lead to lormailon of grariulomaia